Correlation Between Serum CA-125 Levels and Age in Advanced-Stage Epithelial Ovarian Cancer Patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia (2021-2022)
1 Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Département of Clinical Pathology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital Surabaya Indonesia.
3 Département of Obstetrics and Gynecology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital Surabaya, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 895–898
Publication history:
Received on 01 November 2024; revised on 04 December 2024; accepted on 07 December 2024
Abstract:
Ovarian cancer is a gynecological malignancy that originates in the ovaries. Symptoms of ovarian cancer often remain unnoticed in its early stages, leading to a diagnosis at an advanced stage. CA-125 is a widely recognized biomarker used in ovarian cancer for diagnosis, monitoring treatment response, and predicting prognosis. Research has shown that CA-125 levels can vary with age and are influenced by multiple biological factors, including hormonal changes and the progression of ovarian cancer. Age-related factors can influence CA-125 levels, which may affect the interpretation of such examination results. This study aims to determine the correlation between serum CA-125 levels and ages in advanced-stage epithelial ovarian cancer patients. This research is a retrospective study using the comparative analytic research method by taking the medical record data of epithelial ovarian cancer with advanced-stage patients treated in oncology clinic of Dr. Soetomo General Hospital Surabaya for January 1, 2021 – December 2022. Based on the analysis of 61 patient subjects categorized into three age groups, the median serum CA-125 levels for patients aged <40 years were 172.85 U/mL, for those aged 40-50 years the median was 261 U/mL, and for patients aged >50 years the median was 116.2 U/mL. The Kruskal-Wallis test (p-value) yielded a result of 0.518, indicating that there was no statistically significant relationship between serum CA-125 levels of patients and patients’ age (p = 0.518). In addition, there is no correlation between serum CA-125 levels and age in advanced-stage epithelial ovarian cancer patients at Dr. Soetomo General Hospital, Surabaya.
Keywords:
Ovarian Cancer; CA-125; Age; Malignancy; Serum Biomarkers
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