Diarrhea in children with acute lymphoblastic Leukemia: A literature review

Julia Intan Permata Sari 1, Juniastuti 2, * and Mia Ratwita Andarsini 3, 

1 Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
3 Child Health Department, Faculty of Medicine, Universitas Airlangga.
4 Child Health Département, Dr Soetomo Academic General Hospital Surabaya.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 3016-3019
Article DOI: 10.30574/wjarr.2024.24.3.3980
 
Publication history: 
Received on 21 November 2024; revised on 28 December 2024; accepted on 30 December 2024
 
Abstract: 
Acute lymphoblastic leukemia (ALL) in children often leads to gastrointestinal complications such as diarrhea due to chemotherapy, radiation, and immunotherapy treatments. These therapies damage the gut mucosa, disrupt gut microbiota, and increase susceptibility to infections, exacerbating diarrhea. Effective management strategies, including rehydration, probiotics, and selective antibiotics, are essential to mitigate symptoms and prevent complications like dehydration and malnutrition. Long-term approaches focusing on monitoring gut health and dietary interventions, such as prebiotics and probiotics, are crucial for improving the quality of life and supporting recovery in children with ALL.
 
Keywords: 
Diarrhea; Acute Lymphoblastic Leukemia; Chemotherapy; Treatment; Management
 
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